Oseltamivir Carboxylate, the Active Metabolite of Oseltamivir Phosphate (Tamiflu), Detected in Sewage Discharge and River Water in Japan

@inproceedings{Ghosh2010OseltamivirCT,
  title={Oseltamivir Carboxylate, the Active Metabolite of Oseltamivir Phosphate (Tamiflu), Detected in Sewage Discharge and River Water in Japan},
  author={Gopal Chandra Ghosh and Norihide Nakada and Naoyuki Yamashita and Hiroaki Tanaka},
  booktitle={Environmental health perspectives},
  year={2010}
}
BACKGROUND Oseltamivir phosphate (OP; Tamiflu) is a prodrug of the anti-influenza neuraminidase inhibitor oseltamivir carboxylate (OC) and has been developed for the treatment and prevention of both A and B strains of influenza. The recent increase in OP resistance in influenza A virus (H1N1; commonly called "swine flu") has raised questions about the widespread use of Tamiflu in seasonal epidemics and the potential ecotoxicologic risk associated with its use in the event of a pandemic… CONTINUE READING
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Environmental risk assessment for oseltamivir ( Tamiflu ) for sewage works and surface waters under seasonalinfluenzaand pandemicuse conditions

  • SC Sweetman
  • Ecotoxicol Environ Saf
  • 2009

Comparison of the activities of zanamivir , oseltamivir , and RWJ270201 against clinical isolates of influenza virus and neuraminidase inhibitorresistant variants

  • M Huber, S Canonica, GY Park, UV Gunten
  • Antimicrob Agents Chemother
  • 2001

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