Oseltamivir (tamiflu) is a substrate of peptide transporter 1.

  title={Oseltamivir (tamiflu) is a substrate of peptide transporter 1.},
  author={Takuo Ogihara and Takashi Kano and Tamae Wagatsuma and Sho Wada and Hikaru Yabuuchi and Shigeki Enomoto and Kaori Morimoto and Yoshiyuki Shirasaka and Shoko Kobayashi and Ikumi Tamai},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  volume={37 8},
Oseltamivir, an ester-type prodrug of the neuraminidase inhibitor [3R,4R,5S]-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate phosphate (Ro 64-0802), has been developed for the treatment of A and B strains of the influenza virus but has neuropsychiatric and other side effects. In this study, we characterized the transport across intestinal epithelial cells and the absorption of oseltamivir in rats. Uptake by Caco-2 cells (human carcinoma cell line) and HeLa cells transfected… CONTINUE READING


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