Oscillatory signaling and network responses during the development of Dictyostelium discoideum.

@article{McMains2008OscillatorySA,
  title={Oscillatory signaling and network responses during the development of Dictyostelium discoideum.},
  author={Vanessa C. McMains and Xin-hua Liao and Alan R. Kimmel},
  journal={Ageing research reviews},
  year={2008},
  volume={7 3},
  pages={234-48}
}
Periodic biological variations reflect interactions among molecules and cells, or even organisms. The Dictyostelium cAMP oscillatory circuit is a highly robust example. cAMP oscillations in Dictyostelium arise intracellularly by a complex interplay of activating and inhibiting pathways, are transmitted extracellularly, and synchronize an entire local population. Once established, cAMP signal-relay persists stably for hours. On a two-dimensional surface, >100,000 cells may form a single… CONTINUE READING
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