Oscillatory shear stress and hydrostatic pressure modulate cell-matrix attachment proteins in cultured endothelial cells

@article{Thoumine1995OscillatorySS,
  title={Oscillatory shear stress and hydrostatic pressure modulate cell-matrix attachment proteins in cultured endothelial cells},
  author={Olivier Thoumine and Robert M. Nerem and Feggy R. Girard},
  journal={In Vitro Cellular & Developmental Biology - Animal},
  year={1995},
  volume={31},
  pages={45-54}
}
Endothelial cells (ECs) may behave as hemodynamic sensors, translating mechanical information from the blood flow into biochemical signals, which may then be transmitted to underlying smooth muscle cells. The extracellular matrix (ECM), which provides adherence and integrity for the endothelium, may serve an important signaling function in vascular diseases such as atherogenesis, which has been shown to be promoted by low and oscillating shear stresses. In this study, confluent bovine aortic… CONTINUE READING
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