Oscillatory membrane potential response to glucose in islet beta-cells: a comparison of islet-cell electrical activity in mouse and rat.

@article{Fox2006OscillatoryMP,
  title={Oscillatory membrane potential response to glucose in islet beta-cells: a comparison of islet-cell electrical activity in mouse and rat.},
  author={Jocelyn E. Manning Fox and Armen V. Gyulkhandanyan and Leslie S. Satin and Michael B Wheeler},
  journal={Endocrinology},
  year={2006},
  volume={147 10},
  pages={4655-63}
}
In contrast to mouse, rat islet beta-cell membrane potential is reported not to oscillate in response to elevated glucose despite demonstrated oscillations in calcium and insulin secretion. We aim to clarify the electrical activity of rat islet beta-cells and characterize and compare the electrical activity of both alpha- and beta-cells in rat and mouse islets. We recorded electrical activity from alpha- and beta-cells within intact islets from both mouse and rat using the perforated whole-cell… CONTINUE READING
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