Oscillatory Flow Modulates Mechanosensitive klf2a Expression through trpv4 and trpp2 during Heart Valve Development

@article{Heckel2015OscillatoryFM,
  title={Oscillatory Flow Modulates Mechanosensitive klf2a Expression through trpv4 and trpp2 during Heart Valve Development},
  author={Emilie Heckel and Francesco Boselli and St{\'e}phane Roth and Alice Krudewig and Heinz-Georg Belting and Gilles Charvin and Julien Vermot},
  journal={Current Biology},
  year={2015},
  volume={25},
  pages={1354-1361}
}
In vertebrates, heart pumping is required for cardiac morphogenesis and altering myocardial contractility leads to abnormal intracardiac flow forces and valve defects. Among the different mechanical cues generated in the developing heart, oscillatory flow has been proposed to be an essential factor in instructing endocardial cell fate toward valvulogenesis and leads to the expression of klf2a, a known atheroprotective transcription factor. To date, the mechanism by which flow forces are sensed… CONTINUE READING
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Proceedings of the National Academy of Sciences of the United States of America • 2011
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