Oscillator mechanism of Notch pathway in the segmentation clock.

  title={Oscillator mechanism of Notch pathway in the segmentation clock.},
  author={Ryoichiro Kageyama and Yoshito Masamizu and Yasutaka Niwa},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  volume={236 6},
Somites are formed by periodic segmentation of the presomitic mesoderm (PSM). This periodic event is controlled by the segmentation clock, where Notch signaling plays an essential role. The basic helix-loop-helix factor Hes7, a Notch effector, is cyclically expressed by negative feedback and regulates cyclic expression of Lunatic fringe (Lfng), a Notch modulator. Lfng then seems to periodically inhibit Notch, leading to oscillation in Notch activity. It is thought that these coupled negative… CONTINUE READING

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