Oscillations of the snail genes in the presomitic mesoderm coordinate segmental patterning and morphogenesis in vertebrate somitogenesis.

@article{Dale2006OscillationsOT,
  title={Oscillations of the snail genes in the presomitic mesoderm coordinate segmental patterning and morphogenesis in vertebrate somitogenesis.},
  author={J Kim Dale and Pascale Malapert and J{\'e}rome Chal and Gonçalo C. Vilhais-Neto and Miguel Maroto and Teri J. Johnson and Sachintha M Jayasinghe and Paul A Trainor and Bernhard G Herrmann and Olivier Pourqui{\'e}},
  journal={Developmental cell},
  year={2006},
  volume={10 3},
  pages={355-66}
}
The segmented body plan of vertebrate embryos arises through segmentation of the paraxial mesoderm to form somites. The tight temporal and spatial control underlying this process of somitogenesis is regulated by the segmentation clock and the FGF signaling wavefront. Here, we report the cyclic mRNA expression of Snail 1 and Snail 2 in the mouse and chick presomitic mesoderm (PSM), respectively. Whereas Snail genes' oscillations are independent of NOTCH signaling, we show that they require WNT… CONTINUE READING
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Vertebrate Segmentation: Snail Counts the Time until Morphogenesis

Current Biology • 2006
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