Oscillations in an intra-host model of Plasmodium Falciparum malaria due to cross-reactive immune response.

@article{Mitchell2010OscillationsIA,
  title={Oscillations in an intra-host model of Plasmodium Falciparum malaria due to cross-reactive immune response.},
  author={Jonathan L. Mitchell and Thomas W. Carr},
  journal={Bulletin of mathematical biology},
  year={2010},
  volume={72 3},
  pages={
          590-610
        }
}
We consider an intra-host model of malaria that allows for antigenic variation within a single species. More specifically, the host's immune response is compartmentalized into reactions to major and minor epitopes. We investigate the conditions that lead to transient oscillations, which correspond to recurrent clinical episodes of the diseases, and how a small delay in the activation of the immune response can lead to persistent oscillations. We find that the efficacies of the immune responses… CONTINUE READING
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