Oscillations in NF-κB Signaling Control the Dynamics of Gene Expression

@article{Nelson2004OscillationsIN,
  title={Oscillations in NF-$\kappa$B Signaling Control the Dynamics of Gene Expression},
  author={D. E. Nelson and Adaoha Elizabeth Ihekwaba and Martin Elliott and James R. Johnson and Claire A Gibney and B. E. Foreman and Glyn Nelson and Violaine S{\'e}e and Caroline A. Horton and David G. Spiller and S. W. Edwards and Heather P. McDowell and John F. Unitt and Elaine Sullivan and Rachel L. Grimley and Neil Benson and David S. Broomhead and Douglas Bruce Kell and Michael R. H. White},
  journal={Science},
  year={2004},
  volume={306},
  pages={704 - 708}
}
Signaling by the transcription factor nuclear factor kappa B (NF-κB) involves its release from inhibitor kappa B (IκB) in the cytosol, followed by translocation into the nucleus. NF-κB regulation of IκBα transcription represents a delayed negative feedback loop that drives oscillations in NF-κB translocation. Single-cell time-lapse imaging and computational modeling of NF-κB (RelA) localization showed asynchronous oscillations following cell stimulation that decreased in frequency with… 
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