Oscillations by the p53-Mdm2 feedback loop.

@article{Lahav2008OscillationsBT,
  title={Oscillations by the p53-Mdm2 feedback loop.},
  author={Galit Lahav},
  journal={Advances in experimental medicine and biology},
  year={2008},
  volume={641},
  pages={
          28-38
        }
}
  • G. Lahav
  • Published 2008
  • Biology
  • Advances in experimental medicine and biology
The p53 network is perhaps the most important pathway involved in preventing the initiation of cancer, p53 levels and activity are upregulated in response to various stresses including DNA damage, hypoxia, and oncogene activation. Active p53 initiates different transcriptional programs that result in cell cycle arrest, cellular senescence or apoptosis. p53 also activates the transcription of Mdm2, which in turns target p53 for degradation, therefore creating a negative feedback loop on p53… 
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lahav.med.harvard.edu
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