Oscillating glucose induces microRNA-185 and impairs an efficient antioxidant response in human endothelial cells


BACKGROUND Intracellular antioxidant response to high glucose is mediated by Cu/Mn-superoxide dismutases (SOD-1/SOD-2), catalase (CAT) and glutathione peroxidases (GPx), particularly glutathione peroxidase-1 (GPx-1). Although oscillating glucose can induce a more deleterious effect than high glucose on endothelial cells, the mechanism by which oscillating… (More)
DOI: 10.1186/s12933-016-0390-9


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