Oscillating CD8(+) T cell effector functions after antigen recognition in the liver.

@article{Isogawa2005OscillatingCT,
  title={Oscillating CD8(+) T cell effector functions after antigen recognition in the liver.},
  author={Masanori Isogawa and Yoshihiro Furuichi and Francis V. Chisari},
  journal={Immunity},
  year={2005},
  volume={23 1},
  pages={53-63}
}
When hepatitis B virus (HBV)-specific CD8(+) cytotoxic T lymphocytes (CTLs) are adoptively transferred into HBV transgenic mice, they enter the liver, recognize antigen, secrete interferon gamma (IFNgamma), inhibit viral replication, and kill their target cells, causing hepatitis. In the current study, we examined the impact of antigen recognition on the evolution of the activation phenotype, antiviral effector functions, expansion and contraction kinetics, and compartmentalization of the… CONTINUE READING