Orthovanadate induces translocation of phospholipase C-gamma 1 and -gamma 2 in permeabilized mast cells.

@article{Atkinson1993OrthovanadateIT,
  title={Orthovanadate induces translocation of phospholipase C-gamma 1 and -gamma 2 in permeabilized mast cells.},
  author={T Prescott Atkinson and Chang Woo Lee and Sue Goo Rhee and R J Hohman},
  journal={Journal of immunology},
  year={1993},
  volume={151 3},
  pages={1448-55}
}
Rapid activation of phospholipase C (PLC) with a resultant increase in phosphatidylinositol hydrolysis occurs after aggregation of the high affinity receptor for IgE (Fc epsilon RI) on the surface of mast cells. We previously described an increase in PLC activity associated with the particulate fraction of rat basophilic leukemia (RBL) cells after Fc epsilon RI aggregation, and this redistribution of enzyme activity correlated with an increase in immunoreactivity of the gamma 1 isozyme of PLC… CONTINUE READING