Orthotopic models of pediatric brain tumors in zebrafish

  title={Orthotopic models of pediatric brain tumors in zebrafish},
  author={Christopher J. Eden and Bensheng Ju and Mohankumar Murugesan and Timothy N. Phoenix and Birgit Nimmervoll and Yiai Tong and D W Ellison and David B. Finkelstein and Karen D. Wright and Nidal Boulos and Jason Dapper and Radhika Thiruvenkatam and Charles A. Lessman and Michael David Taylor and Richard J. Gilbertson},
High-throughput screens (HTS) of compound toxicity against cancer cells can identify thousands of potential new drug-leads. But only limited numbers of these compounds can progress to expensive and labor-intensive efficacy studies in mice, creating a ‘bottle neck’ in the drug development pipeline. Approaches that triage drug-leads for further study are greatly needed. Here we provide an intermediary platform between HTS and mice by adapting mouse models of pediatric brain tumors to grow as… CONTINUE READING
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