Orthotopic models of cancer for preclinical drug evaluation: advantages and disadvantages

@article{Bibby2004OrthotopicMO,
  title={Orthotopic models of cancer for preclinical drug evaluation: advantages and disadvantages},
  author={Michael Charles Bibby},
  journal={European journal of cancer},
  year={2004},
  volume={40 6},
  pages={852-7}
}
Considering the enormous effort that has taken place over the years to discover new chemotherapeutic drugs for treating the common cancers, the conventional murine and xenograft test systems used to test efficacy for drug development have identified only a limited number of useful agents that are active clinically at well tolerated doses. In recent years, considerable effort has been made to develop more clinically relevant models by the use of orthotopic transplantation of tumour material in… CONTINUE READING

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