Orthotopic liver transplantation, Epstein-Barr virus, cyclosporine, and lymphoproliferative disease: a growing concern.

@article{Malatack1991OrthotopicLT,
  title={Orthotopic liver transplantation, Epstein-Barr virus, cyclosporine, and lymphoproliferative disease: a growing concern.},
  author={J Feffrey Malatack and J. Carlton Gartner and A. H. Urbach and Basil J. Zitelli},
  journal={The Journal of pediatrics},
  year={1991},
  volume={118 5},
  pages={
          667-75
        }
}
Lymphoproliferative disease (LPD) is a well-recognized complication of both solid organ and bone marrow transplantations. The occurrence of LPD in these settings is related in part to the use of the immunosuppressive agent cyclosporine. We report 12 cases of LPD after orthotopic liver transplantations in 132 pediatric patients. Lymphoproliferative disease occurred as one of three clinical syndromes: (1) lymphadenopathic, (2) systemic, and (3) lymphomatous. Effective management of LPD with… CONTINUE READING

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