Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency.

  title={Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency.},
  author={J. Richard Shannon and Nancy L Flattem and Jens Jordan and Giris Jacob and Bonnie K. Black and Italo Biaggioni and Randy D. Blakely and David J. Robertson},
  journal={The New England journal of medicine},
  volume={342 8},
BACKGROUND Orthostatic intolerance is a syndrome characterized by lightheadedness, fatigue, altered mentation, and syncope and associated with postural tachycardia and plasma norepinephrine concentrations that are disproportionately high in relation to sympathetic outflow. We tested the hypothesis that impaired functioning of the norepinephrine transporter contributes to the pathophysiologic mechanism of orthostatic intolerance. METHODS In a patient with orthostatic intolerance and her… CONTINUE READING
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