Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells in vitro.

@article{Reffitt2003OrthosilicicAS,
  title={Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells in vitro.},
  author={David M Reffitt and Nc Ogston and Ravin Jugdaohsingh and Hang Fat Cheung and Bronwen Alice James Evans and Richard P.H. Thompson and Jonathan Joseph Powell and Geeta N Hampson},
  journal={Bone},
  year={2003},
  volume={32 2},
  pages={
          127-35
        }
}
Silicon deficiency in animals leads to bone defects. This element may therefore play an important role in bone metabolism. Silicon is absorbed from the diet as orthosilicic acid and concentrations in plasma are 5-20 microM. The in vitro effects of orthosilicic acid (0-50 microM) on collagen type 1 synthesis was investigated using the human osteosarcoma cell line (MG-63), primary osteoblast-like cells derived from human bone marrow stromal cells, and an immortalized human early osteoblastic cell… CONTINUE READING
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