Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells in vitro.

@article{Reffitt2003OrthosilicicAS,
  title={Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells in vitro.},
  author={D. Reffitt and N. Ogston and R. Jugdaohsingh and H. Cheung and B. Evans and R. P. Thompson and J. Powell and G. Hampson},
  journal={Bone},
  year={2003},
  volume={32 2},
  pages={
          127-35
        }
}
  • D. Reffitt, N. Ogston, +5 authors G. Hampson
  • Published 2003
  • Biology, Medicine
  • Bone
  • Silicon deficiency in animals leads to bone defects. This element may therefore play an important role in bone metabolism. Silicon is absorbed from the diet as orthosilicic acid and concentrations in plasma are 5-20 microM. The in vitro effects of orthosilicic acid (0-50 microM) on collagen type 1 synthesis was investigated using the human osteosarcoma cell line (MG-63), primary osteoblast-like cells derived from human bone marrow stromal cells, and an immortalized human early osteoblastic cell… CONTINUE READING
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    References

    SHOWING 1-10 OF 42 REFERENCES
    Zeolite a increases proliferation, differentiation, and transforming growth factor β production in normal adult human osteoblast‐like cells in vitro
    • 215
    The role of type I collagen in the regulation of the osteoblast phenotype
    • S. Shi, M. Kirk, A. Kahn
    • Biology, Medicine
    • Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
    • 1996
    • 124
    Osteocalcin secretion by the human osteosarcoma cell line MG‐63
    • 117
    Isolation and characterization of osteoblast precursor cells from human bone marrow
    • 368
    Differential Cell Surface Expression of the STRO‐1 and Alkaline Phosphatase Antigens on Discrete Developmental Stages in Primary Cultures of Human Bone Cells
    • 290
    • PDF
    Short-term effects of organic silicon on trabecular bone in mature ovariectomized rats
    • 100
    Marrow stromal cell commitment to mineralization under the effect of a prolyl hydroxylase inhibitor
    • 10
    Regulation of alkaline phosphatase by 1,25‐dihydroxyvitamin D3 and ascorbic acid in bone‐derived cells
    • R. Franceschi, J. Young
    • Chemistry, Medicine
    • Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
    • 1990
    • 95
    The effects of cadmium, copper or zinc on formation of embryonic chick bone in tissue culture.
    • 38