Orthomolecular Psychiatry

@article{Pauling1968OrthomolecularP,
  title={Orthomolecular Psychiatry},
  author={Linus. Pauling},
  journal={Science},
  year={1968},
  volume={160},
  pages={265 - 271}
}
  • L. Pauling
  • Published 19 April 1968
  • Medicine, Psychology
  • Science
The functioning of the brain is affected by the molecular concentrations of many substances that are normally present in the brain. The optimum concentrations of these substances for a person may differ greatly from the concentrations provided by his normal diet and genetic machinery. Biochemical and genetic arguments support the idea that orthomolecular therapy, the provision for the individual person of the optimum concentrations of important normal constituents of the brain, may be the… 
Conditionally Essential Nutrients: The State of the Science
TLDR
Biochemical and ge-netic arguments support the idea that orthomolecular therapy, the provision for the individual person of the optimum concen-trations of important normal constituents of the brain, may be the preferred treatment for many mentally ill patients.
An Orthomolecular Theory of Human Health and Disease
TLDR
The evidence indicates that ascorbate insufficiency is the most important cause of poor health, with the blood level of apopro-tein(a) also contributing, as well as insufficiencies in some other vitamins and some endogenous substances.
On the orthomolecular environment of the mind: orthomolecular theory.
TLDR
There is sound evidence for the theory that increased intake of such vitamins as ascorbic acid, niacin, pyridoxine, and cyanocobalamin is useful in treating schizophrenia, and the negative conclusions of APA Task Force Report 7 result from faulty arguments and from a bias against megavitamin therapy.
Can " Schizophrenia " Reflect Changes in the Blood-Brain Barrier System ?
TLDR
There are psychological and organic theories to explain the etiology of these complex collections and systems of behavior and within these two groups there are genetic theories, neurochemical theories, abnormal metabolite theories, analytic theories, behavioral theories, cognitive theories and many more.
Vitamins in Psychiatry
TLDR
Although clearly less effective than antipsychotic drug treatment, vitamin therapy is not without risks — adverse effects have been reported with nicotinic acid, pyridoxine and vitamin C.
Nutrition and schizophrenia: Implications and problems
TLDR
It is not possible to say that malnutrition in early life is an aetiological factor in any psychiatric disorder, but nutrient deficiencies during the first 2 years or so of postnatal life may have their sequel in poor function later.
The Unique Vulnerability of the Human Brain to Toxic Chemical Exposure and the Importance of Toxic Chemical Evaluation and Treatment in Orthomolecular Psychiatry
The human brain and the brains of whales and dolphins (cetaceans) are especially suscep- tible to a variety of toxic chemicals because of natural selection that favors brain structures promoting
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