Orthogonally Photocontrolled Non-Autonomous DNA Walker.

  title={Orthogonally Photocontrolled Non-Autonomous DNA Walker.},
  author={Marko {\vS}kugor and Juli{\'a}n Valero and Keiji Murayama and Mathias Centola and Hiroyuki Asanuma and Michael Famulok},
  journal={Angewandte Chemie},
  volume={58 21},
There is considerable interest in developing progressively moving devices on the nanoscale, with the aim of using them as parts of programmable therapeutics, smart materials, and nanofactories. Present here is an entirely light-induced DNA walker based on orthogonal photocontrol. Implementing two azobenzene derivatives, S-DM-Azo and DM-Azo, enabled precise coordination of strand displacement reactions that powered a biped walker and guided it along a defined track in a non-autonomous way. This… 
34 Citations

Regeneration of Burnt Bridges on a DNA Catenane Walker

The path regeneration of a burnt‐bridges DNA catenane walker using RNase A is reported, showing that RNA degradation triggered by RNase A restores the path and returns the walker to the initial position.

Research progress of DNA walker and its recent applications in biosensor

Mechanisms, methods of tracking and applications of DNA walkers: A review.

  • Julián Valero Moreno
  • Biology, Art
    Chemphyschem : a European journal of chemical physics and physical chemistry
  • 2020
This review will cover the various examples and breakthrough designs of recently reported DNA walkers that pushed the limits of their performance, and mention the techniques that have been used to investigate walker nanosystems, as well as discuss the applications that have be explored so far.

Photoresponsive DNA materials and their applications.

A comprehensive overview of exciting developments in the design of photoresponsive DNA materials is provided, and a range of applications in catalysis, sensing and drug delivery/release are showcased.

Interlocked DNA Nanojoints for Reversible Thermal Sensing

The design, assembly, and characterization of a group of thermal‐responsive deoxyribonucleic acid (DNA) joints, consisting of two interlocked double‐stranded DNA (dsDNA) rings, is described and the temperature response range of the DNA nanojoint is largely unaffected by its own concentration.



Building a nanostructure with reversible motions using photonic energy.

The principle employed in this study, photoisomerization-induced toehold length switching, could be further useful in the design of other mechanical devices, with the ultimate goal of rivaling molecular motors for cargo transport and macroscopic movement.

An autonomous and controllable light-driven DNA walking device.

A novel light-powered DNA mechanical device, which is reminiscent of cellular protein motors in nature, is presented, capable of autonomous locomotion, with light control of initiation, termination and velocity.

Temporal and Reversible Control of a DNAzyme by Orthogonal Photoswitching.

Orthogonally photoswitchable DNAzyme-based catalysts as introduced here have potential use for controlling complex logical operations and for future applications in DNA nanodevices.

Bipedal nanowalker by pure physical mechanisms.

A light-powered DNA bipedal walker based on a design principle derived from cellular walkers that has a distinct thermodynamic feature that it possesses the same equilibrium before and after operation, but generates a truly nonequilibrium distribution during operation.

Reversible Light Switch for Macrocycle Mobility in a DNA Rotaxane

Two different approaches for the reversible switching of a double-stranded DNA rotaxane architecture from a stationary pseudorotaxane mode into a state with movable components are described.

DNA-based nanoscale walking devices and their applications

This paper reviews DNA walking devices based on walking functions including unipedal, bipedal, multipedsal, and other novel walking devices, as well as their applications.

A DNAzyme that walks processively and autonomously along a one-dimensional track.

A DNA nanodevice that autonomously and processively moves along a DNA track that is in sharp contrast with cellular protein motors and manmade machines at the macroscale, both of which can continuously work without human interference.

Allosteric Control of Oxidative Catalysis by a DNA Rotaxane Nanostructure.

The design of an interlocked DNA nanostructure is reported that is able to fine-tune the oxidative catalytic activity of a split DNAzyme in a highly controllable manner and shows that multiple switching steps between the active and inactive conformations can be performed consistent with efficient regulation and robust control of the DNA Nanostructure.

Orthogonal photoswitching in a multifunctional molecular system

This work reports the orthogonal and reversible control of two distinct types of photoswitches in one solution, that is, a donor–acceptor Stenhouse adduct (DASA) and an azobenzene and a model application for an intramolecular combination of switches is presented.

Synthetic molecular walkers.

Both DNA-based and small-molecule walkers are reviewed, including their designs, dynamics, and how they are being used to perform functions by controlled mechanical motion at the molecular level.