Orthogonal functionalisation of α-helix mimetics† †Electronic supplementary information (ESI) available: Additional binding data and fluorescence characterisation. Experimental procedures and characterisation of all new compounds. See DOI: 10.1039/c4ob00915k Click here for additional data file.

@inproceedings{Barnard2014OrthogonalFO,
  title={Orthogonal functionalisation of α-helix mimetics†
†Electronic supplementary information (ESI) available: Additional binding data and fluorescence characterisation. Experimental procedures and characterisation of all new compounds. See DOI: 10.1039/c4ob00915k
Click here for additional data file.

},
  author={Anna Barnard and K{\'e}rya Long and David J. Yeo and Jennifer A Miles and Valeria Azzarito and George M Burslem and Panchami Prabhakaran and Thomas A. Edwards and Andrew J. Wilson},
  booktitle={Organic & biomolecular chemistry},
  year={2014}
}
α-Helix mediated protein-protein interactions are of major therapeutic importance. As such, the design of inhibitors of this class of interaction is of significant interest. We present methodology to modify N-alkylated aromatic oligoamide α-helix mimetics using 'click' chemistry. The effect is shown to modulate the binding properties of a series of… CONTINUE READING