Orthogonal analytical approaches to detect potential contaminants in heparin.

@article{Guerrini2009OrthogonalAA,
  title={Orthogonal analytical approaches to detect potential contaminants in heparin.},
  author={Marco Guerrini and Zhenqing Zhang and Zachary H. Shriver and Annamaria Naggi and Sayaka Masuko and Robert Langer and Benito Casu and Robert J. Linhardt and Giangiacomo Torri and Ram Sasisekharan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 40},
  pages={
          16956-61
        }
}
Heparin is a widely used anticoagulant and antithrombotic agent. Recently, a contaminant, oversulfated chondroitin sulfate (OSCS), was discovered within heparin preparations. The presence of OSCS within heparin likely led to clinical manifestations, most prevalently, hypotension and abdominal pain leading to the deaths of several dozens of patients. Given the biological effects of OSCS, one continuing item of concern is the ability for existing methods to identify other persulfonated… CONTINUE READING

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