Orthogonal analytical approaches to detect potential contaminants in heparin

@article{Guerrini2009OrthogonalAA,
  title={Orthogonal analytical approaches to detect potential contaminants in heparin},
  author={M. Guerrini and Zhenqing Zhang and Z. Shriver and A. Naggi and Sayaka Masuko and R. Langer and B. Casu and R. Linhardt and G. Torri and R. Sasisekharan},
  journal={Proceedings of the National Academy of Sciences},
  year={2009},
  volume={106},
  pages={16956 - 16961}
}
Heparin is a widely used anticoagulant and antithrombotic agent. Recently, a contaminant, oversulfated chondroitin sulfate (OSCS), was discovered within heparin preparations. The presence of OSCS within heparin likely led to clinical manifestations, most prevalently, hypotension and abdominal pain leading to the deaths of several dozens of patients. Given the biological effects of OSCS, one continuing item of concern is the ability for existing methods to identify other persulfonated… Expand
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