Orthodontic treatment of patients with sickle-cell anemia.

  title={Orthodontic treatment of patients with sickle-cell anemia.},
  author={Patricia V. M. Alves and Daniele Karina M Alves and Margareth Maria Gomes de Souza and Sandra Torres},
  journal={The Angle orthodontist},
  volume={76 2},
Sickle-cell anemia is a genetic blood disease characterized by a hemoglobin gene mutation. The genetic failure is basically constituted by replacement of the hemoglobin beta chain in the sixth position so that the amino acid valine is encoded instead of glutamic acid. As a result, the erythrocytes have their normal biconcave discoid shape distorted, generally presenting a sicklelike shape, which reduces both their plasticity and lifetime. Because a complete blood supply is so important during… CONTINUE READING

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