Orthodontic tooth movement and de novo synthesis of proinflammatory cytokines.

  title={Orthodontic tooth movement and de novo synthesis of proinflammatory cytokines.},
  author={Najat Alhashimi and Lars Frithiof and Pongsri Brudvik and Moiz Bakhiet},
  journal={American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics},
  volume={119 3},
Interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) are proinflammatory cytokines that are thought to play a role in bone remodeling, bone resorption, and new bone deposition. In the present work, in situ hybridization was performed to measure the messenger RNA expression of IL-1beta, IL-6, and TNF-alpha at 3, 7, and 10 days after the application of orthodontic force on the maxillary first molars of 12 rats. The contralateral side and 3 untreated rats… CONTINUE READING


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