Ortho-substituted but not coplanar PCBs rapidly kill cerebellar granule cells.

  title={Ortho-substituted but not coplanar PCBs rapidly kill cerebellar granule cells.},
  author={Yuansheng Tan and Renji Song and David Lawrence and D. E. O. S. Carpenter},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  volume={79 1},
Several PCB congeners were assessed for their cytotoxicity on cerebellar granule cells in an attempt to compare their structure-activity relationship as potential neurotoxicants and to assess the mechanisms associated with their toxicity. Flow cytometry was used to monitor the changes of a number of biochemical endpoints: membrane integrity, intracellular free calcium concentration ([Ca(2+)](i)), reactive oxygen species (ROS) production, mitochondrial membrane potential (Delta psi(m)), and cell… CONTINUE READING


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