Orphanin FQ reduces morphine-induced dopamine release in the nucleus accumbens: a microdialysis study in rats.

Abstract

The effects induced by orphanin FQ (OFQ) on morphine-induced dopamine (DA), 3,4-dihydroxyphenilacetic acid (DOPAC) and homovanillic acid (HVA) release in the nucleus accumbens were studied in rats by using microdialysis with electrochemical detection. Morphine administered intraperitoneally (i.p., 2, 5 and 10 mg/kg) dose-dependently increased DA and metabolites release in the nucleus accumbens. OFQ intracerebroventricularly (i.c.v.) administered at doses of 2, 5 and 10 nmol did not change DA and metabolites release in the nucleus accumbens. OFQ (10 nmol) administered i.c.v. 15 min before morphine (5 and 10 mg/kg, i.p.) significantly reduced morphine-induced DA and metabolites release in the nucleus accumbens. These effects suggest that OFQ may regulate the stimulant action linked to morphine-induced DA release in the nucleus accumbens.

Statistics

0200400600'02'04'06'08'10'12'14'16
Citations per Year

1,067 Citations

Semantic Scholar estimates that this publication has 1,067 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Giannuario1999OrphaninFR, title={Orphanin FQ reduces morphine-induced dopamine release in the nucleus accumbens: a microdialysis study in rats.}, author={Amalia Di Giannuario and Stefano Pieretti and Assia Catalani and Anna Livia Loizzo}, journal={Neuroscience letters}, year={1999}, volume={272 3}, pages={183-6} }