Orphanin FQ inhibits synaptic transmission and long-term potentiation in rat hippocampus.

@article{Yu1997OrphaninFI,
  title={Orphanin FQ inhibits synaptic transmission and long-term potentiation in rat hippocampus.},
  author={T P Yu and Joel Fein and T Phan and C. John Evans and C W Xie},
  journal={Hippocampus},
  year={1997},
  volume={7 1},
  pages={88-94}
}
It is known that opioid peptides acting on opioid receptors can modulate hippocampal synaptic functions. Although a novel member of the opioid receptor family, ORL1 receptors, that displays high-sequence homology with classical opioid receptors is abundant in the hippocampus, little is known regarding its role in synaptic function. The present study was designed to investigate whether activation of the ORL1 receptor by its natural ligand, orphanin FQ, could modulate synaptic transmission and… CONTINUE READING
30 Extracted Citations
46 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 30 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 46 references

Immunohistochemical localization of ORL-1 in the central nervous system of the rat

  • B Anton, J Fein, ToT, L Silberstein, CJ Evans
  • J. Comp. Neurol
  • 1996
6 Excerpts

Similar Papers

Loading similar papers…