Orphan receptor tyrosine kinases ROR1 and ROR2 in hematological malignancies.

  title={Orphan receptor tyrosine kinases ROR1 and ROR2 in hematological malignancies.},
  author={Amir Hossein Daneshmanesh and Anna A Porwit and M Hojjat-Farsangi and Mahmood Jeddi-Tehrani and Katja Pokrovskaja Tamm and Dan Grand{\'e}r and S{\"o}ren Lehmann and Stefan Norin and Fazel Shokri and Hodjattallah Rabbani and H{\aa}kan Mellstedt and Anders {\"O}sterborg},
  journal={Leukemia & lymphoma},
  volume={54 4},
The receptor tyrosine kinase ROR1 has been shown to be overexpressed in chronic lymphocytic leukemia (CLL). The aim of this study was to further characterize the expression of ROR1 and the other member of the ROR family, ROR2, in other lymphoid and myeloid malignancies. Normal white blood cells and reactive lymph nodes were negative for ROR1 and ROR2. A significantly high and uniform surface expression of ROR1 was found in CLL/hairy cell leukemia (HCL) compared to mantle cell lymphoma (MCL… CONTINUE READING