Orphan receptor tyrosine kinase ROR2 as a potential therapeutic target for osteosarcoma.

  title={Orphan receptor tyrosine kinase ROR2 as a potential therapeutic target for osteosarcoma.},
  author={Kazuhito Morioka and Chizu Tanikawa and Kensuke Ochi and Yataro Daigo and Toyomasa Katagiri and Hirotaka Kawano and Hiroshi Kawaguchi and Akira Myoui and Hideki Yoshikawa and Norifumi Naka and Nobuto Araki and Ikuo Kudawara and Makoto Ieguchi and Kozo Nakamura and Yusuke Nakamura and Koichi Matsuda},
  journal={Cancer science},
  volume={100 7},
Osteosarcoma is the most prevalent bone malignant tumor in children and adolescents, and displays heterogeneous histology and high propensity for distant metastasis. Although adjuvant chemotherapy remarkably improved treatment outcome over the past few decades, prognosis for osteosarcoma patients with pulmonary metastasis is still unsatisfactory. To identify novel therapeutic targets for osteosarcoma, we investigated the gene expression profile of osteosarcomas by cDNA microarray analysis and… CONTINUE READING
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