Orphan receptor promiscuity in the induction of cytochromes p450 by xenobiotics.

@article{Smirlis2001OrphanRP,
  title={Orphan receptor promiscuity in the induction of cytochromes p450 by xenobiotics.},
  author={Despina Smirlis and Roongsiri Muangmoonchai and Mina Edwards and Ian R. Phillips and Elizabeth A Shephard},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 16},
  pages={12822-6}
}
The mechanisms by which different classes of chemicals induce the same cytochrome P450 (CYP) or the same chemical differentially induces more than one CYP are not well understood. We show that in primary hepatocytes and in vivo in liver (transfected by particle-mediated delivery) two orphan nuclear receptors, constitutive androstane receptor and pregnane X receptor (PXR1), transactivate a CYP gene via the same response element in a xenobiotic-specific manner. The constitutive androstane… CONTINUE READING
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