Orphan receptor GPR158 controls stress-induced depression

  title={Orphan receptor GPR158 controls stress-induced depression},
  author={Laurie P Sutton and Cesare Orlandi and Chenghui Song and Won Chan Oh and Brian S Muntean and Keqiang Xie and Alice Filippini and Xiangyang Xie and Rachel Satterfield and Jazmine D. W. Yaeger and Kenneth J. Renner and Samuel M Young and Baoji Xu and Hyungbae Kwon and Kirill A Martemyanov},
Stress can be a motivational force for decisive action and adapting to novel environment; whereas, exposure to chronic stress contributes to the development of depression and anxiety. However, the molecular mechanisms underlying stress-responsive behaviors are not fully understood. Here, we identified the orphan receptor GPR158 as a novel regulator operating in the prefrontal cortex (PFC) that links chronic stress to depression. GPR158 is highly upregulated in the PFC of human subjects with… CONTINUE READING
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