Orphan receptor Arp-1 binds to the nucleotide sequence located between TATA box and transcriptional initiation site of the human angiotensinogen gene and reduces estrogen induced promoter activity.

@article{Narayanan1999OrphanRA,
  title={Orphan receptor Arp-1 binds to the nucleotide sequence located between TATA box and transcriptional initiation site of the human angiotensinogen gene and reduces estrogen induced promoter activity.},
  author={Chittampalli S. Narayanan and Yanning Cui and Yan Zhao and Jie Zhou and Ashok Kumar},
  journal={Molecular and cellular endocrinology},
  year={1999},
  volume={148 1-2},
  pages={79-86}
}
Human angiotensinogen gene contains a C/A polymorphism at 20 bases upstream from the transcriptional initiation site. This sequence binds to the estrogen receptor when nucleoside A is present at this site and reporter constructs containing human angiotensinogen gene promoter with nucleoside A at -20 are transactivated on co-transfection of estrogen receptor in HepG2 cells followed by estrogen treatment. We show here that orphan receptor, Arp-1, which belongs to the COUP family of transcription… CONTINUE READING