Orphan nuclear receptor pregnane X receptor sensitizes oxidative stress responses in transgenic mice and cancerous cells.

@article{Gong2006OrphanNR,
  title={Orphan nuclear receptor pregnane X receptor sensitizes oxidative stress responses in transgenic mice and cancerous cells.},
  author={Haibiao Gong and Shivendra V Singh and Sharda P Singh and Ying Mu and Jeong Hoon Lee and Simrat P S Saini and David Tom{\'a} and Songrong Ren and Valerian E Kagan and Billy W. Day and Piotr Zimniak and Wen Xie},
  journal={Molecular endocrinology},
  year={2006},
  volume={20 2},
  pages={279-90}
}
Efficient handling of oxidative stress is critical for the survival of organisms. The orphan nuclear receptor pregnane X receptor (PXR) is important in xenobiotic detoxification through its regulation of phase I and phase II drug-metabolizing/detoxifying enzymes and transporters. In this study we unexpectedly found that the expression of an activated human PXR in transgenic female mice resulted in a heightened sensitivity to paraquat, an oxidative xenobiotic toxicant. Heightened paraquat… CONTINUE READING

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