Orphan nuclear receptor estrogen-related receptor alpha is essential for adaptive thermogenesis.

@article{Villena2007OrphanNR,
  title={Orphan nuclear receptor estrogen-related receptor alpha is essential for adaptive thermogenesis.},
  author={Josep A. Villena and M. Benjamin Hock and William Y Chang and Joanalyn E Barcas and Vincent Gigu{\`e}re and Anastasia Kralli},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 4},
  pages={1418-23}
}
Survival of organisms requires the ability to adapt to changes in the environment. Adaptation of oxidative metabolism is essential for meeting increased energy demands in response to stressors, such as exposure to cold temperatures or increased physical activity. Adaptive changes in metabolism are often achieved at the level of gene expression, and nuclear receptors have prevalent roles in mediating such responses. Estrogen-related receptor alpha (ERRalpha) was the first orphan nuclear receptor… CONTINUE READING
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