Orphan nuclear receptor Nur77 induces zinc finger protein GIOT-1 gene expression, and GIOT-1 acts as a novel corepressor of orphan nuclear receptor SF-1 via recruitment of HDAC2.

@article{Song2006OrphanNR,
  title={Orphan nuclear receptor Nur77 induces zinc finger protein GIOT-1 gene expression, and GIOT-1 acts as a novel corepressor of orphan nuclear receptor SF-1 via recruitment of HDAC2.},
  author={Kwang Hoon Song and Youngsook Park and Hae Jin Kee and Cheol Yi Hong and Yong-soo Lee and Seung-Won Ahn and Hye-Jin Kim and Keesook Lee and Hyun Yi Kook and Shinrye Lee and Hueng-Sik Choi},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 23},
  pages={
          15605-14
        }
}
Kruppel-associated box (KRAB) domain-containing proteins consist of potential transcriptional repression modules. Previously, gonadotropin-inducible ovarian transcription factor-1 (GIOT-1) was identified as a novel KRAB-containing zinc finger protein and shown to have transcriptional repression activity. Here, we demonstrate that orphan nuclear receptor Nur77 regulates GIOT-1 gene expression in testicular Leydig cell lines and that GIOT-1 acts as a novel corepressor of the orphan nuclear… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 14 CITATIONS

Similar Papers

Loading similar papers…