Orphan neurones and amine excess: the functional neuropathology of Parkinsonism and neuropsychiatric disease.

@article{Willis1998OrphanNA,
  title={Orphan neurones and amine excess: the functional neuropathology of Parkinsonism and neuropsychiatric disease.},
  author={Gregory L. Willis and Stuart M. Armstrong},
  journal={Brain research. Brain research reviews},
  year={1998},
  volume={27 3},
  pages={177-242}
}
The aetiology and treatment of Parkinsonism is currently conceptualised within a dopamine (DA) deficiency-repletion framework. Loss of striatal DA is thought to cause motor impairment of which tremor, bradykinaesia and rigidity are prominent features. Repletion of deficient DA should at least minimise parkinsonian signs and symptoms. In Section 2, based on extensive pre-clinical and clinical findings, the instability of this approach to Parkinsonism is scrutinised as the existing negative… CONTINUE READING