Orphan GPCR target validation.

  title={Orphan GPCR target validation.},
  author={William J. Thomsen and James M. Leonard and Dominic P. Behan},
  journal={Current opinion in molecular therapeutics},
  volume={6 6},
Nearly half of the identified non-olfactory G protein-coupled receptors (GPCRs) have no identified cognate ligand. These 'orphan' receptors are likely to have important physiological roles that could potentially be exploited therapeutically. However, by definition, such receptors are not immediately open for pharmacological investigation of their function. Here we summarize several strategic approaches to facilitate the discovery of orphan GPCR biology. 

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