Orphan G-protein-coupled receptors and natural ligand discovery.

  title={Orphan G-protein-coupled receptors and natural ligand discovery.},
  author={Andrew D. Howard and G Mcallister and Scott D. Feighner and Qingyun J Liu and Ravi P Nargund and Lex H T Van der Ploeg and Arthur A. Patchett},
  journal={Trends in pharmacological sciences},
  volume={22 3},
The superfamily of seven-transmembrane-domain G-protein-coupled receptors (GPCRs) is the largest and most diverse group of transmembrane proteins involved in signal transduction. Each of the approximately 1000 family members found in vertebrates responds to stimuli as diverse as hormones, neurotransmitters, odorants and light, which selectively activate intracellular signaling events mediated by heterotrimeric G proteins. Because GPCRs are centrally positioned in the plasma membrane to initiate… CONTINUE READING

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