Orphan G protein-coupled receptor GPRC5A modulates integrin β1-mediated epithelial cell adhesion.

Abstract

G-Protein Coupled Receptor (GPCR), Class C, Group 5, Member A (GPRC5A) has been implicated in several malignancies. The underlying mechanisms, however, remain poorly understood. Using a panel of human cell lines, we demonstrate that CRISPR/Cas9-mediated knockout and RNAi-mediated depletion of GPRC5A impairs cell adhesion to integrin substrates: collagens I… (More)
DOI: 10.1080/19336918.2016.1245264

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Cite this paper

@article{Bulanova2017OrphanGP, title={Orphan G protein-coupled receptor GPRC5A modulates integrin β1-mediated epithelial cell adhesion.}, author={Daria R Bulanova and Yevhen A Akimov and Anne Rokka and Teemu Daniel Laajala and Tero Aittokallio and Petri Kouvonen and Teijo Pellinen and Sergey G. Kuznetsov}, journal={Cell adhesion & migration}, year={2017}, volume={11 5-6}, pages={434-446} }