Orphan Comparisons and Indirect Meta-analysis: A Case Study on Antidepressant Efficacy in Dysthymia Comparing Tricyclic Antidepressants, Selective Serotonin Reuptake Inhibitors, and Monoamine Oxidase Inhibitors by Using General Linear Models

@article{Ballesteros2005OrphanCA,
  title={Orphan Comparisons and Indirect Meta-analysis: A Case Study on Antidepressant Efficacy in Dysthymia Comparing Tricyclic Antidepressants, Selective Serotonin Reuptake Inhibitors, and Monoamine Oxidase Inhibitors by Using General Linear Models},
  author={Javier Ballesteros},
  journal={Journal of Clinical Psychopharmacology},
  year={2005},
  volume={25},
  pages={127-131}
}
  • J. Ballesteros
  • Published 2005
  • Psychology, Medicine
  • Journal of Clinical Psychopharmacology
Abstract: Direct comparisons of the efficacy of competing interventions are not always available in the literature. This situation leads to the presence of clinically relevant "orphan comparisons" of therapeutic interventions which have never been compared head-to-head. To overcome this limitation, simple methods for indirect meta-analysis have been suggested. Nevertheless, their results are prone to bias when more than 1 indirect comparison is tested because of the likely duplication of data… Expand
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