Orphan Comparisons and Indirect Meta-analysis: A Case Study on Antidepressant Efficacy in Dysthymia Comparing Tricyclic Antidepressants, Selective Serotonin Reuptake Inhibitors, and Monoamine Oxidase Inhibitors by Using General Linear Models

@article{Ballesteros2005OrphanCA,
  title={Orphan Comparisons and Indirect Meta-analysis: A Case Study on Antidepressant Efficacy in Dysthymia Comparing Tricyclic Antidepressants, Selective Serotonin Reuptake Inhibitors, and Monoamine Oxidase Inhibitors by Using General Linear Models},
  author={Javier Ballesteros},
  journal={Journal of Clinical Psychopharmacology},
  year={2005},
  volume={25},
  pages={127-131}
}
  • J. Ballesteros
  • Published 1 April 2005
  • Psychology
  • Journal of Clinical Psychopharmacology
Abstract: Direct comparisons of the efficacy of competing interventions are not always available in the literature. This situation leads to the presence of clinically relevant "orphan comparisons" of therapeutic interventions which have never been compared head-to-head. To overcome this limitation, simple methods for indirect meta-analysis have been suggested. Nevertheless, their results are prone to bias when more than 1 indirect comparison is tested because of the likely duplication of data… 
Sensitivity to Excluding Treatments in Network Meta-analysis
TLDR
This article examines the influence of treatment exclusion empirically using 14 published network meta-analyses, for both arm- and contrast-based approaches, and the difference between these two approaches is substantial.
Estrogen-receptor status and outcomes of modern chemotherapy for patients with node-positive breast cancer
TLDR
Among patients with node-positive tumors, ER-negative breast cancer, biweekly doxorubicin/cyclophosphamide plus paclitaxel lowers the rate of recurrence and death by more than 50% in comparison with low-dose cycloph phosphamide, doxorbicin, and fluorouracil as used in the first study.
Assessing key assumptions of network meta‐analysis: a review of methods
TLDR
In the malaria example, consistency was questionable; therefore the NMA results may be unreliable; therefore, existing assessment methods collectively are advocated to gain the best understanding possible regarding whether assumptions are reasonable.
Bayesian Hierarchical Methods for Network Meta-Analysis
TLDR
This dissertation presents a meta-analyses of the determinants of infectious disease in eight operation rooms of the immune system and shows clear patterns of disease progression that are consistent with those of a community-based approach.
A THESIS SUBMITTED TO THE FACULTY OF THE GRADUATE SCHOOL OF THE UNIVERSITY OF MINNESOTA BY Yuan Li IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY
TLDR
This thesis contributes efficient exact solutions in low dimensions (2D and 3D), and a new sampling-based approximation algorithm in higher dimensions, where each line has an associated existence probability representing uncertainty that is inherent in real-world data.
Multivariate extension of meta-analysis
Οι κλασικές μέθοδοι μετά-ανάλυσης περιορίζονται στην περίπτωση της σύγκρισης δύο θεραπευτικών παρεμβάσεων. Στην κλινική πράξη, ωστόσο, υπάρχουν συνήθως πολλές εναλλακτικές παρεμβάσεις που μπορούν να
The Impact of Excluding Trials from Network Meta-Analyses – An Empirical Study
TLDR
This article empirically examines the impact of trial exclusion using both the arm-based and contrast-based approaches, by reanalyzing 20 published NMAs involving 725 randomized controlled trials and 449,325 patients and recommends rigorous inclusion and exclusion criteria, logical study selection process, and reasonable network geometry to ensure robustness and generalizability of the results of NMAs.
Acute nocturnal akathisia induced by clozapine.
TLDR
Akathisia, a subjective complaint of restlessness accompanied by observed movements of the legs, is one of the most disagreeable extrapyramidal side effects of medications and often causes noncompliance in patients with schizophrenia.
Stemmingsstoornissen
...
...

References

SHOWING 1-10 OF 30 REFERENCES
Efficacy and tolerability of selective serotonin reuptake inhibitors compared with tricyclic antidepressants in depression treated in primary care: systematic review and meta-analysis
TLDR
The evidence on the relative efficacy of selective serotonin reuptake inhibitors and tricyclic antidepressants in primary care is sparse and of variable quality and the study setting is likely to be an important factor in assessing the efficacy and tolerability of treatment with antidepressant drugs.
The efficacy of drug treatments for dysthymia: a systematic review and meta-analysis
TLDR
Drug treatment appears to be effective in the short-term management of dysthymic disorder and the choice of drug should take into account specific side-effects profile of each drug.
Are SSRIs better than TCAs? Comparison of SSRIs and TCAs: A meta‐analysis
TLDR
Patients taking SSRIs experienced significantly more gastrointestinal problems and sexual dysfunction, whereas treatment with TCAs produced significantly more complaints of sedation, dizziness, and anticholinergic symptoms.
A placebo-controlled, randomized clinical trial comparing sertraline and imipramine for the treatment of dysthymia.
TLDR
Pharmacotherapy provides considerable relief from the symptoms of dysthymia in patients suffering from this chronic affective disorder, with both sertraline and imipramine being more effective than placebo.
A randomized double-blind study of fluoxetine versus placebo in the treatment of dysthymia.
TLDR
Fluoxetine subjects showed significantly greater improvement at week 8 than placebo subjects on the Hamilton depression and CGI scales, but not on the Hopkins Symptom Check-list (58-item) or the Cornell Dysthymia Rating Scale.
Moclobemide and imipramine in chronic depression (dysthymia): an international double‐blind, placebo‐controlled trial
TLDR
This study demonstrates the efficacy of high dose moclobemide and high dose imipramine against placebo in the treatment of dysthymia and the investigators' final overall assessment of tolerability significantly favoured mociohemide over imipramsine.
Imipramine treatment for chronic depression.
TLDR
Anti-depressant medication was effective for many moderately severe chronic depressions, which had previously been untreated or undertreated, presumably related to misdiagnosis.
...
...