Orphan Comparisons and Indirect Meta-analysis: A Case Study on Antidepressant Efficacy in Dysthymia Comparing Tricyclic Antidepressants, Selective Serotonin Reuptake Inhibitors, and Monoamine Oxidase Inhibitors by Using General Linear Models

@article{Ballesteros2005OrphanCA,
  title={Orphan Comparisons and Indirect Meta-analysis: A Case Study on Antidepressant Efficacy in Dysthymia Comparing Tricyclic Antidepressants, Selective Serotonin Reuptake Inhibitors, and Monoamine Oxidase Inhibitors by Using General Linear Models},
  author={Javier Ballesteros},
  journal={Journal of Clinical Psychopharmacology},
  year={2005},
  volume={25},
  pages={127-131}
}
  • J. Ballesteros
  • Published 1 April 2005
  • Psychology
  • Journal of Clinical Psychopharmacology
Abstract: Direct comparisons of the efficacy of competing interventions are not always available in the literature. This situation leads to the presence of clinically relevant "orphan comparisons" of therapeutic interventions which have never been compared head-to-head. To overcome this limitation, simple methods for indirect meta-analysis have been suggested. Nevertheless, their results are prone to bias when more than 1 indirect comparison is tested because of the likely duplication of data… 

Sensitivity to Excluding Treatments in Network Meta-analysis

TLDR
This article examines the influence of treatment exclusion empirically using 14 published network meta-analyses, for both arm- and contrast-based approaches, and the difference between these two approaches is substantial.

Acute nocturnal akathisia induced by clozapine.

TLDR
Akathisia, a subjective complaint of restlessness accompanied by observed movements of the legs, is one of the most disagreeable extrapyramidal side effects of medications and often causes noncompliance in patients with schizophrenia.

The Impact of Excluding Trials from Network Meta-Analyses – An Empirical Study

TLDR
This article empirically examines the impact of trial exclusion using both the arm-based and contrast-based approaches, by reanalyzing 20 published NMAs involving 725 randomized controlled trials and 449,325 patients and recommends rigorous inclusion and exclusion criteria, logical study selection process, and reasonable network geometry to ensure robustness and generalizability of the results of NMAs.

GetReal in network meta‐analysis: a review of the methodology

TLDR
This article presents a review of the relevant literature on NMA methodology aiming to pinpoint the developments that have appeared in the field.

Estrogen-receptor status and outcomes of modern chemotherapy for patients with node-positive breast cancer

TLDR
Among patients with node-positive tumors, ER-negative breast cancer, biweekly doxorubicin/cyclophosphamide plus paclitaxel lowers the rate of recurrence and death by more than 50% in comparison with low-dose cycloph phosphamide, doxorbicin, and fluorouracil as used in the first study.

Estrogen-receptor status and outcomes of modern chemotherapy for patients with node-positive breast cancer.

TLDR
Among patients with node-positive tumors, ER-negative breast cancer, biweekly doxorubicin/cyclophosphamide plus paclitaxel lowers the rate of recurrence and death by more than 50% in comparison with low-dose cycloph phosphamide, doxorbicin, and fluorouracil as used in the first study.

Assessing key assumptions of network meta‐analysis: a review of methods

TLDR
In the malaria example, consistency was questionable; therefore the NMA results may be unreliable; therefore, existing assessment methods collectively are advocated to gain the best understanding possible regarding whether assumptions are reasonable.

Bayesian Hierarchical Methods for Network Meta-Analysis

TLDR
This dissertation presents a meta-analyses of the determinants of infectious disease in eight operation rooms of the immune system and shows clear patterns of disease progression that are consistent with those of a community-based approach.

A THESIS SUBMITTED TO THE FACULTY OF THE GRADUATE SCHOOL OF THE UNIVERSITY OF MINNESOTA BY Yuan Li IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY

TLDR
This thesis contributes efficient exact solutions in low dimensions (2D and 3D), and a new sampling-based approximation algorithm in higher dimensions, where each line has an associated existence probability representing uncertainty that is inherent in real-world data.

References

SHOWING 1-10 OF 30 REFERENCES

Efficacy and tolerability of selective serotonin reuptake inhibitors compared with tricyclic antidepressants in depression treated in primary care: systematic review and meta-analysis

TLDR
The evidence on the relative efficacy of selective serotonin reuptake inhibitors and tricyclic antidepressants in primary care is sparse and of variable quality and the study setting is likely to be an important factor in assessing the efficacy and tolerability of treatment with antidepressant drugs.

The efficacy of drug treatments for dysthymia: a systematic review and meta-analysis

TLDR
Drug treatment appears to be effective in the short-term management of dysthymic disorder and the choice of drug should take into account specific side-effects profile of each drug.

Are SSRIs better than TCAs? Comparison of SSRIs and TCAs: A meta‐analysis

TLDR
Patients taking SSRIs experienced significantly more gastrointestinal problems and sexual dysfunction, whereas treatment with TCAs produced significantly more complaints of sedation, dizziness, and anticholinergic symptoms.

Review of comparative clinical trials. Moclobemide vs tricyclic antidepressants and vs placebo in depressive states.

TLDR
When the tolerability of moclobemide, as judged by reported and observed adverse events, is compared to that of placebo, it appears that only nausea is reported significantly more frequently with moclOBemide than with placebo; in particular the incidence of anticholinergic side effects was low with mclobemides and was significantly higher with the TCAs.

A placebo-controlled, randomized clinical trial comparing sertraline and imipramine for the treatment of dysthymia.

TLDR
Pharmacotherapy provides considerable relief from the symptoms of dysthymia in patients suffering from this chronic affective disorder, with both sertraline and imipramine being more effective than placebo.

Validity of indirect comparison for estimating efficacy of competing interventions: empirical evidence from published meta-analyses

TLDR
Results of adjusted indirect comparison usually, but not always, agree with those of head to head randomised trials The validity ofadjusted indirect comparisons depends on the internal validity and similarity of the trials involved.

Controlled efficacy study of fluoxetine in dysthymia

TLDR
The finding that 50% of the non-responders at 3 months were improved at 6 months, after fluoxetine dosage was increased to 40 mg daily, argues in favour of treating dysthymic patients for at least 6 years, and with a higher dosage if the initial doses are ineffective.