Oroxylin A improves attention deficit hyperactivity disorder-like behaviors in the spontaneously hypertensive rat and inhibits reuptake of dopamine in vitro

  title={Oroxylin A improves attention deficit hyperactivity disorder-like behaviors in the spontaneously hypertensive rat and inhibits reuptake of dopamine in vitro},
  author={Seo Young Yoon and Ike C Dela Pe{\~n}a and Sung Mok Kim and Tae Sun Woo and Chan Young Shin and Kun Ho Son and Haeil Park and Yong Soo Lee and Jong Hoon Ryu and Mingli Jin and Kyeong-man Kim and Jae Hoon Cheong},
  journal={Archives of Pharmacal Research},
In previous studies we have demonstrated that the γ-aminobutryic acid-A (GABA-A) receptor antagonist oroxylin A has an awakening effect and it also represses ADHD-like behaviors (hyperactivity, impulsivity and inattention) in the spontaneously hypertensive rat (SHR) model of attention-deficit hyperactivity disorder (ADHD). We hypothesized that the effects of oroxylin A were exerted via the GABA-A receptor given the important role of the GABAergic system in ADHD. However, it is possible that… 
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