Oroxylin A improves attention deficit hyperactivity disorder-like behaviors in the spontaneously hypertensive rat and inhibits reuptake of dopamine in vitro

@article{Yoon2013OroxylinAI,
  title={Oroxylin A improves attention deficit hyperactivity disorder-like behaviors in the spontaneously hypertensive rat and inhibits reuptake of dopamine in vitro},
  author={Seo Young Yoon and I. D. Dela Pe{\~n}a and Sung Mok Kim and Tae Sun Woo and C. Shin and K. Son and H. Park and Y. Lee and J. Ryu and Mingli Jin and K. Kim and J. Cheong},
  journal={Archives of Pharmacal Research},
  year={2013},
  volume={36},
  pages={134-140}
}
In previous studies we have demonstrated that the γ-aminobutryic acid-A (GABA-A) receptor antagonist oroxylin A has an awakening effect and it also represses ADHD-like behaviors (hyperactivity, impulsivity and inattention) in the spontaneously hypertensive rat (SHR) model of attention-deficit hyperactivity disorder (ADHD). We hypothesized that the effects of oroxylin A were exerted via the GABA-A receptor given the important role of the GABAergic system in ADHD. However, it is possible that… Expand
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