Oroxylin A has therapeutic potential in acute myelogenous leukemia by dual effects targeting PPARγ and RXRα.

@article{Hui2014OroxylinAH,
  title={Oroxylin A has therapeutic potential in acute myelogenous leukemia by dual effects targeting PPARγ and RXRα.},
  author={Hui Hui and Yan Chen and Hao Yang and Kai Zhao and Qian Wang and Lu Zhao and Xiaotang Wang and Zhiyu Li and Na Lu and Qinglong Guo},
  journal={International journal of cancer},
  year={2014},
  volume={134 5},
  pages={1195-206}
}
Oroxylin A (OA) is a flavonoid derived from a Chinese herb that has previously been reported to inhibit the proliferation of several cancer cell lines. It is found that OA significantly inhibited the growth of myeloid leukemia cell lines and as xenografts in immunodeficient mice and primary blasts from acute myelogenous leukemia (AML) patients. Furthermore, OA-induced cell cycle arrest and differentiation were observed in OA-treated AML cell lines. OA-induced increase of CD11b/CD14 expression… CONTINUE READING
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