Orotidylate-metabolizing enzymes of the human malarial parasite, Plasmodium falciparum, differ from host cell enzymes.

@article{Rathod1983OrotidylatemetabolizingEO,
  title={Orotidylate-metabolizing enzymes of the human malarial parasite, Plasmodium falciparum, differ from host cell enzymes.},
  author={Pradipsinh K Rathod and Pedro Reyes},
  journal={The Journal of biological chemistry},
  year={1983},
  volume={258 5},
  pages={2852-5}
}
Orotate phosphoribosyltransferase and orotidylate decarboxylase from mammalian sources reside on a bifunctional protein. In such a system, orotidylate, the product of orotate phosphoribosyltransferase is preferentially channeled to orotidylate decarboxylase and does not equilibrate with the assay medium. In contrast, we found that orotidylate was released into the medium during the conversion of orotate to uridylate by cell-free extract of Plasmodium falciparum. Furthermore, orotate… CONTINUE READING