Corpus ID: 7604920

Orotic acid, nucleotide-pool imbalance, and liver-tumor promotion: a possible mechanism for the mitoinhibitory effects of orotic acid in isolated rat hepatocytes.

@article{Manjeshwar1992OroticAN,
  title={Orotic acid, nucleotide-pool imbalance, and liver-tumor promotion: a possible mechanism for the mitoinhibitory effects of orotic acid in isolated rat hepatocytes.},
  author={S. Manjeshwar and A. Sheikh and G. Pichiri-Coni and P. Coni and P. Rao and S. Rajalakshmi and P. Pediaditakis and G. Michalopoulos and D. Sarma},
  journal={Cancer research},
  year={1992},
  volume={52 7 Suppl},
  pages={
          2078s-2081s
        }
}
This study was designed to determine the possible mechanism by which orotic acid exerts its mitoinhibitory effect on rat hepatocytes in primary culture. Orotic acid inhibited, dose-dependently DNA synthesis in hepatocytes induced by epidermal growth factor, transforming growth factor alpha, hepatocyte growth factor, acidic fibroblast growth factor, or plasma from rats exposed to various liver cell-proliferative stimuli, such as two-thirds partial hepatectomy, lead nitrate, cyproterone acetate… Expand
Influence of Orotic Acid on Multistage Hepatocarcinogenesis in the Rat: Resistance of Hepatocytes from Nodules to the Mitoinhibitory Effects of Orotic Acid
Nitrogen-stimulated orotic acid synthesis and nucleotide imbalance.
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References

SHOWING 1-10 OF 63 REFERENCES
Studies on the mitoinhibitory effect of orotic acid on hepatocytes in primary culture.
Inhibition of DNA synthesis in primary cultures of hepatocytes by orotic acid.
Dietary orotic acid enhances the incidence of gamma-glutamyltransferase positive foci in rat liver induced by chemical carcinogens.
Orotic Acid, a New Promoter for Experimental Liver Carcinogenesis
Promotion by orotic acid of liver carcinogenesis in rats initiated by 1,2-dimethylhydrazine.
Dietary and Metabolic Manipulations of the Carcinogenic Process: Role of Nucleotide Pool Imbalances in Carcinogenesis
Dietary orotic acid, a new selective growth stimulus for carcinogen altered hepatocytes in rat.
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4
5
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