Orotate phosphoribosyltransferase levels measured by a newly established enzyme-linked immunosorbent assay in gastric carcinoma.

@article{Sakurai2006OrotatePL,
  title={Orotate phosphoribosyltransferase levels measured by a newly established enzyme-linked immunosorbent assay in gastric carcinoma.},
  author={Yoichi Sakurai and Kazuki Sakamoto and Yoshikazu Sugimoto and Inez Val{\'e}ria Pagotto Yoshida and Toshihiko Masui and Shuhei Tonomura and Kazuki Inaba and Mitsutaka Shoji and Yasuko Nakamura and Ichiro Uyama and Yoshiyuki Komori and Masahiro Ochiai and Shiro Matsuura and Hideyuki Tanaka and Toshinori Oka and Masakazu Fukushima},
  journal={Cancer science},
  year={2006},
  volume={97 6},
  pages={
          492-8
        }
}
A number of enzymes have been shown to be involved in the process of activation and/or degradation of 5-fluorouracil (5-FU), and are potential candidates for predicting chemosensitivity to 5-FU. Among these, orotate phosphoribosyltransferase (OPRT EC 2.4.2.10) is a key enzyme related to the first-step activation process of 5-FU and has been shown to be an important enzyme that helps to predict sensitivity to 5-FU and its related derivatives. We developed a new enzyme-linked immunosorbent assay… CONTINUE READING
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