Oropharyngeal carcinoma related to human papillomavirus

  title={Oropharyngeal carcinoma related to human papillomavirus},
  author={Hisham M. Mehanna and Terence M. Jones and Vincent Gr{\'e}goire and K. Kian Ang},
  journal={BMJ : British Medical Journal},
Incidence is increasing rapidly, with implications for prognosis and policy 

Oropharyngeal squamous cell carcinoma in the veteran population: Association with traditional carcinogen exposure and poor clinical outcomes

A significant fraction of oropharyngeal squamous cell carcinoma (SCC) cases is associated with traditional carcinogens; in these patients, treatment response and clinical outcomes remain poor.

Radiographic muscle invasion not a recurrence predictor in HPV‐associated oropharyngeal squamous cell carcinoma

To determine whether muscle invasion evident on pretreatment imaging in p16 + oropharyngeal squamous cell carcinoma (OPSCC) correlates with recurrence, Pretreatment Imaging is used as a surrogate for recurrence.

Human papillomavirus prevalence and prognostic implication in oropharyngeal squamous cell carcinomas

Evaluating the prevalence and prognostic significance of the HPV infection through both the p16 expression status and the oncogenic HPV DNA viral load found that HPV‐related oropharyngeal squamous cell carcinoma is associated with favorable survival.

Trends in the incidence of oral cavity and oropharyngeal cancers in Spain

The purpose of this study was to analyze and compare incidence trends of oral cavity and oropharyngeal cancers, using data from population‐based Spanish cancer registries.

Geographic variation in human papillomavirus–related oropharyngeal cancer: Data from 4 multinational randomized trials

There are variations in the proportions of head and neck cancers caused by the human papillomavirus (HPV) between countries and regions. It is unclear if these are true variations or due to different

Smoking and papillomavirus DNA in patients with p16‐positive N3 oropharyngeal squamous cell carcinoma

The survival of patients with a p16‐positive N3 oropharyngeal squamous cell carcinoma and the prognostic significance of patient, tumor, and treatment characteristics are investigated.

A 20‐year retrospective study of tonsil cancer incidence and survival trends in South East England: 1987–2006

Clin. Otolaryngol. 2011, 36, 325–335

Prevalence of human papillomavirus in oropharyngeal and nonoropharyngeal head and neck cancer—systematic review and meta‐analysis of trends by time and region

Little information has been reported on regional and time trends of human papillomavirus (HPV) prevalence rates of oropharyngeal cancer (OPC) and non‐OPC.

Fastest increasing cancer in Scotland, especially in men

Using data from the Scottish Cancer Registry, it is found that oropharyngeal cancer now has the highest prevalence in the UK, compared with two years ago.

Squamous cell carcinoma of the oral tongue: Distinct epidemiological profile disease

The goal was to investigate the epidemiological features of OSCC with relation to age and subsite and to establish a smoking cessation strategy for this cancer.



Human papillomavirus positive squamous cell carcinoma of the oropharynx

The authors retrospectively determined the presence of the virus and the integrity of the viral E2 gene in tumors of patients who have undergone curative irradiation of patients with squamous cell carcinoma of the oropharynx.

Inaccurate assumptions about oropharyngeal cancer

The article by Kim and Goldie on the cost effectiveness of including boys in a human papillomavirus (HPV) vaccination programme made assumptions about oropharyngeal cancers that are inaccurate.1 The

Presence of human papillomavirus in tonsillar cancer is a favourable prognostic factor for clinical outcome.

HPV-positive cancer exhibits less genetic instability i.e. shows a lower degree of aneuploidy and a tendency to have fewer chromosomal aberrations, when compared to HPV-negative tonsillar cancer.

Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial.

For patients with HNSCC of the oropharynx, tumor HPV status is strongly associated with therapeutic response and survival and, after adjustment for age, tumor stage, and ECOG performance status, lower risks of progression and death are found.

Incidence of human papillomavirus (HPV) positive tonsillar carcinoma in Stockholm, Sweden: An epidemic of viral‐induced carcinoma?

The incidence of HPV‐positive cancers is still increasing in the County of Stockholm, suggesting an epidemic of a virus‐induced carcinoma, with soon practically all tonsillar SCC being HPV positive, as in cervical cancer.

Chemoselection as a strategy for organ preservation in advanced oropharynx cancer: response and survival positively associated with HPV16 copy number.

  • F. WordenB. Kumar T. Carey
  • Medicine
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2008
Although the numbers in this study are small, IC followed by CRT is an effective treatment for SCCOP, especially in patients with HPV-positive tumors; however, for patients who do not respond to treatment, alternative treatments must be developed.

Association of tobacco (T) use with risk of distant metastases (DM), tumor recurrence, and death in patients (pts) with HPV-positive (+) squamous cell cancer of the oropharynx (SCCOP).

  • F. WordenJ. Hooton T. Carey
  • Medicine
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2009
Never-T users with HPV-positive SCCOP have improved survival & reduced risk of disease progression compared to HPV (+) & HPV (-) former & current T users.

Survival outcomes by tumor human papillomavirus (HPV) status in stage III-IV oropharyngeal cancer (OPC) in RTOG 0129.

  • M. GillisonJ. Harris K. Ang
  • Medicine
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2009
Tumor HPV status is strongly associated with OS/PFS among OPC patients receiving standard of care chemo-radiation, and should now be a stratification factor for all clinical trials including OPC cases, and separate trials based on THS should be considered.

Sexual behaviours and the risk of head and neck cancers: a pooled analysis in the International Head and Neck Cancer Epidemiology (INHANCE) consortium.

Sexual behaviours are associated with cancer risk at the head and neck cancer subsites that have previously been associated with HPV infection.

Cost effectiveness analysis of including boys in a human papillomavirus vaccination programme in the United States

Assessing the cost effectiveness of including preadolescent boys in a routine human papillomavirus (HPV) vaccination programme for pread adolescent girls generally exceeds conventional thresholds of good value for money, even under favourable conditions of vaccine protection and health benefits.