Oropharyngeal carcinoma related to human papillomavirus

@article{Mehanna2010OropharyngealCR,
  title={Oropharyngeal carcinoma related to human papillomavirus},
  author={Hisham M. Mehanna and Terence M. Jones and Vincent Gr{\'e}goire and K. Kian Ang},
  journal={BMJ : British Medical Journal},
  year={2010},
  volume={340}
}
Incidence is increasing rapidly, with implications for prognosis and policy 

Oropharyngeal squamous cell carcinoma in the veteran population: Association with traditional carcinogen exposure and poor clinical outcomes

A significant fraction of oropharyngeal squamous cell carcinoma (SCC) cases is associated with traditional carcinogens; in these patients, treatment response and clinical outcomes remain poor.

Radiographic muscle invasion not a recurrence predictor in HPV‐associated oropharyngeal squamous cell carcinoma

To determine whether muscle invasion evident on pretreatment imaging in p16 + oropharyngeal squamous cell carcinoma (OPSCC) correlates with recurrence, Pretreatment Imaging is used as a surrogate for recurrence.

Human papillomavirus prevalence and prognostic implication in oropharyngeal squamous cell carcinomas

Evaluating the prevalence and prognostic significance of the HPV infection through both the p16 expression status and the oncogenic HPV DNA viral load found that HPV‐related oropharyngeal squamous cell carcinoma is associated with favorable survival.

Trends in the incidence of oral cavity and oropharyngeal cancers in Spain

The purpose of this study was to analyze and compare incidence trends of oral cavity and oropharyngeal cancers, using data from population‐based Spanish cancer registries.

Geographic variation in human papillomavirus–related oropharyngeal cancer: Data from 4 multinational randomized trials

There are variations in the proportions of head and neck cancers caused by the human papillomavirus (HPV) between countries and regions. It is unclear if these are true variations or due to different

Smoking and papillomavirus DNA in patients with p16‐positive N3 oropharyngeal squamous cell carcinoma

The survival of patients with a p16‐positive N3 oropharyngeal squamous cell carcinoma and the prognostic significance of patient, tumor, and treatment characteristics are investigated.

A 20‐year retrospective study of tonsil cancer incidence and survival trends in South East England: 1987–2006

Clin. Otolaryngol. 2011, 36, 325–335

Prevalence of human papillomavirus in oropharyngeal and nonoropharyngeal head and neck cancer—systematic review and meta‐analysis of trends by time and region

Little information has been reported on regional and time trends of human papillomavirus (HPV) prevalence rates of oropharyngeal cancer (OPC) and non‐OPC.

Fastest increasing cancer in Scotland, especially in men

Using data from the Scottish Cancer Registry, it is found that oropharyngeal cancer now has the highest prevalence in the UK, compared with two years ago.

Squamous cell carcinoma of the oral tongue: Distinct epidemiological profile disease

The goal was to investigate the epidemiological features of OSCC with relation to age and subsite and to establish a smoking cessation strategy for this cancer.
...

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The authors retrospectively determined the presence of the virus and the integrity of the viral E2 gene in tumors of patients who have undergone curative irradiation of patients with squamous cell carcinoma of the oropharynx.

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The article by Kim and Goldie on the cost effectiveness of including boys in a human papillomavirus (HPV) vaccination programme made assumptions about oropharyngeal cancers that are inaccurate.1 The

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Although the numbers in this study are small, IC followed by CRT is an effective treatment for SCCOP, especially in patients with HPV-positive tumors; however, for patients who do not respond to treatment, alternative treatments must be developed.

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Never-T users with HPV-positive SCCOP have improved survival & reduced risk of disease progression compared to HPV (+) & HPV (-) former & current T users.

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Tumor HPV status is strongly associated with OS/PFS among OPC patients receiving standard of care chemo-radiation, and should now be a stratification factor for all clinical trials including OPC cases, and separate trials based on THS should be considered.

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