Oropharyngeal Squamous Cell Carcinoma

  title={Oropharyngeal Squamous Cell Carcinoma},
  author={Zohaib Jamal and Fatima Anjum},
Oropharyngeal squamous cell carcinoma (OPSCC), commonly known as throat cancer or tonsil cancer, refers to the cancer of the middle part of the pharynx, known as oropharynx, which extends vertically from the soft palate to the superior area of the hyoid bone and includes the base and posterior one-third of the tongue, the tonsils, soft palate, and posterior and lateral pharyngeal walls.More than 90% of oropharyngeal cancers are squamous cell cancers, which is the cell lining of the oropharynx… 


[Oral cancer -diagnosis and therapy-.]
Oral cancer is a malignant neoplasm that occurs in the oral cavity, and others include adenocarcinoma derived from minor salivary gland, sarcoma, malignant lymphoma and metastatic cancer, where tongue carcinomas accounts is the most common and accounts for 40% of oral cancers.
Human Papillomavirus in Non-Oropharyngeal Head and Neck Cancers: A Systematic Literature Review
The published data strongly support the need for studies on patients with oral and laryngeal carcinomas that will be powered to find any differences in clinical outcome with respect to HR-HPV and p16 overexpression and suggest an association between HPV and certain salivary gland neoplasms.
Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy.
There is evidence of a small increase in overall survival associated with induction chemotherapy compared to locoregional treatment alone, and there is insufficient evidence as to which agent or regimen is most effective and the additional toxicity associated with chemotherapy given in addition to radiotherapy and/or surgery cannot be quantified.
Human papillomavirus-related oropharyngeal cancer
Accumulated knowledge regarding the role of HPV in OPSCC spanning from infection to cancer development, including its clinical diagnosis, management and preventive strategies is reviewed.
Oral sex and human papilloma virus-related head and neck squamous cell cancer: a review of the literature
The aim of this review of literature is to analyse if there is a strong evidence to correlate oral sex with HPV related HNSCC and counsel the patient’s regarding sexual behaviours.
The role of human papillomavirus on the prognosis and treatment of oropharyngeal carcinoma
The clinical and molecular characteristics of HPV-positive OPC that contribute to its improved prognosis compared to HPV-negative HNC are reviewed and potential mechanisms of treatment sensitivity and the role of therapeutic de-intensification are discussed.
High-Risk Human Papillomavirus in Oral Cancer: Clinical Implications
The potential for the use of de-intensified therapy and prophylactic prevention in HPV-positive oral cancer patients is highlighted, highlighting the unique clinical and molecular pathologic features, prognosis and therapeutic strategies in the prevention and management of HPV- positive oral cancers.
Survival outcomes in patients with oropharyngeal cancer treated with carboplatin/paclitaxel and concurrent radiotherapy
The overall, disease-free and locoregional recurrence-free survival of patients treated with carboplatin and radiotherapy for advanced stage OPSCC parallels what has been described in the literature for cisplatin, with an acceptable side effect profile.
Evidence for a causal association between human papillomavirus and a subset of head and neck cancers.
It is suggested that HPV-positive oropharyngeal cancers comprise a distinct molecular, clinical, and pathologic disease entity that is likely causally associated with HPV infection and that has a markedly improved prognosis.
Transoral laser microsurgery for the treatment of oropharyngeal cancer: the Dalhousie University experience
Observed 36-month efficacy and safety outcomes support the use of TLM for the treatment of primary and recurrent oropharyngeal carcinoma.