Oropharyngeal Colostrum Administration in Extremely Premature Infants: An RCT

@article{Lee2015OropharyngealCA,
  title={Oropharyngeal Colostrum Administration in Extremely Premature Infants: An RCT},
  author={Juyoung Lee and Han-Suk Kim and Young Hwa Jung and Ka young Choi and Seung Han Shin and Ee Kyung Kim and Jung Hwan Choi},
  journal={Pediatrics},
  year={2015},
  volume={135},
  pages={e357 - e366}
}
OBJECTIVE To determine the immunologic effects of oropharyngeal colostrum administration in extremely premature infants. [] Key MethodMETHODS We conducted a double-blind, randomized, placebo-controlled trial involving 48 preterm infants born before 28 weeks' gestation. Subjects received 0.2 mL of their mother's colostrum or sterile water via oropharyngeal route every 3 hours for 3 days beginning at 48 to 96 hours of life.
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Highly Influential Citations
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Background Citations
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Methods Citations
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Results Citations
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Citation Type

Oropharyngeal Colostrum Administration in Very Low Birth Weight Infants: A Randomized Controlled Trial*
TLDR
Oropharyngeal administration of colostrum can increases the level of lactoferrin in saliva in very low birth weight infants.
Randomized Controlled Trial of Oropharyngeal Colostrum Administration in Very-low-birth-weight Preterm Infants.
TLDR
This study found no statistically significant differences between colostrum and placebo groups in the incidence of late-onset clinical sepsis and in concentrations of immunoglobulin A (IgA) in very-low-birth-weight (VLBW) infants, and suggested that oropharyngeal administration ofcolostrum should be reserved for neonates who cannot be fed in first few days of life.
Oropharyngeal Colostrum Positively Modulates the Inflammatory Response in Preterm Neonates
TLDR
Oropharyngeal mother’s milk administration for 15 days decreases the pro-inflammatory state of preterm neonates and provides full enteral nutrition earlier, which could have a positive influence on the development of the immune system and inflammatory response, thereby positively influencing other developmental outcomes.
Colostrum oropharyngeal immunotherapy for very low birth weight preterm infants: protocol of an intervention study
TLDR
This measure facilitates and systematizes clinical care, organizes the team’s work process, speeds up the intervention steps, standardizes decision-making and unifies the quality of care, besides showing the feasibility of oropharyngeal colostrum immunotherapy.
Colostrum oropharyngeal immunotherapy for very low birth weight preterm infants: protocol of an intervention study
TLDR
This measure facilitates and systematizes clinical care, organizes the team's work process, speeds up the intervention steps, standardizes decision-making and unifies the quality of care, besides showing the feasibility of oropharyngeal colostrum immunotherapy in very low birth weight preterm newborns in a neonatal unit.
Oral Application of Colostrum and Mother’s Own Milk in Preterm Infants—A Randomized, Controlled Trial
TLDR
OMOM decreases the incidence of late-onset sepsis in preterm neonates (260/7–306/7 wk) and is safe and there were no significant differences in mortality, NEC, IVH, BPD, ROP, and time to full feeds.
Early oral colostrum administration in preterm infants
TLDR
Administration of OC by syringe and higher cumulative dose are associated with increased absorption of sIgA and lactoferrin, and early dosing may contribute to a more diverse tracheal microbiome.
Role of Oropharyngeal Administration of Colostrum in Very-Low-Birth-Weight Infants for Reducing Necrotizing Enterocolitis: A Randomized Controlled Trial.
TLDR
OAC is safe and reduces the duration of hospital stay in very-low-birth-weight infants and the incidence of NEC was comparable between the two groups.
Oropharyngeal colostrum in preventing mortality and morbidity in preterm infants.
TLDR
If early (within the first 48 hours of life) oropharyngeal administration of mother's own fresh or frozen/thawed colostrum can reduce rates of NEC, late-onset invasive infection, and/or mortality in preterm infants compared with controls is investigated.
Oropharyngeal colostrum in preventing mortality and morbidity in preterm infants
TLDR
Researchers found no significant differences between OPC and control for primary outcomes - incidence of NEC, incidence of late-onset infection, and death before hospital discharge, and meta-analysis showed no difference in length of hospital stay.
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