Orogastric administration of crushed darunavir tablets for a critically ill patient.

  title={Orogastric administration of crushed darunavir tablets for a critically ill patient.},
  author={Catherine H Kim and Katie M. Muzevich and Patricia Pecora Fulco},
  journal={The Canadian journal of hospital pharmacy},
  volume={67 1},
When HIV-positive patients are critically ill and unable to take medications orally, administration of highly active antiretroviral therapy (HAART) becomes challenging. The foremost issue is the lack of parenteral formulations and oral suspensions. Only limited clinical evidence directly addresses the conversion of antiretroviral drugs from the oral to the enteral route. Interruption of HAART is not an acceptable alternative, as this results in HIV viral rebound, immunodeficiency, opportunistic… CONTINUE READING
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